| 罗哌卡因蛛网膜下腔阻滞用于盆腔手术的量效关系 |
| |
| 引用本文： | 刘新春,王秀清,刁莹,王海琴,刘伟荣.罗哌卡因蛛网膜下腔阻滞用于盆腔手术的量效关系[J].临床误诊误治,2011,24(9):20-22. |
| |
| 作者姓名： | 刘新春 王秀清 刁莹 王海琴 刘伟荣 |
| |
| 作者单位： | 包头医学院第一附属医院麻醉科,内蒙古包头,014010 |
| |
| 摘 要： | 目的研究罗哌卡因蛛网膜下腔阻滞用于盆腔手术的量效关系。方法选择择期盆腔手术患者100例,随机、双盲分为A、B、C、D 4组,每组各25例。于腰2～3间隙蛛网膜下腔穿刺成功后,分别注射罗哌卡因15.0 mg(A组)、17.5 mg(B组)、20.0 mg(C组)、22.5 mg(D组)。测定感觉阻滞平面和下肢运动神经阻滞程度,计算镇痛有效率、观察腹壁松弛度,记录麻醉后不良反应。计算50%和95%患者镇痛有效的罗哌卡因剂量(ED50和ED95)及其95%可信区间(CI)。结果 4组感觉阻滞起效时间、最高感觉阻滞平面差异均无统计学意义(P>0.05)。运动阻滞起效时间、感觉和运动恢复时间、最大运动阻滞程度各组间比较差异均有统计学意义(P<0.05,P<0.01)。镇痛有效率、腹壁松弛度组间比较差异均有统计学意义(P<0.05,P<0.01)。罗哌卡因的ED50为15.95 mg(95%CI为15.31～16.62 mg),ED95为18.76 mg(95%CI为17.67～19.54 mg)。结论罗哌卡因中枢神经系统和心血管系统不良反应发生率低,是盆腔手术蛛网膜下腔阻滞的理想药物。
|
| 关 键 词： | 蛛网膜下腔 罗哌卡因 剂量效应关系 药物 |
Dose-effect Relationship of Cavitas Subarachnoidealis Anesthesia with Ropivacaine in Pelvic Surgery |
| |
| LIU Xin-chun,WANG Xiu-qing,DIAO Ying,WANG Hai-qin,LIU Wei-rong.Dose-effect Relationship of Cavitas Subarachnoidealis Anesthesia with Ropivacaine in Pelvic Surgery[J].Clinical Misdiagnosis & Mistherapy,2011,24(9):20-22. |
| |
| Authors: | LIU Xin-chun WANG Xiu-qing DIAO Ying WANG Hai-qin LIU Wei-rong |
| |
| Institution: | LIU Xin-chun,WANG Xiu-qing,DIAO Ying,WANG Hai-qin,LIU Wei-rong(Department of Anaesthesiology,the First Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia 014010,China) |
| |
| Abstract: | Objective To investigate the dose-effect relationship of cavitas subarachnoidealis anesthesia with Ropivacaine in pelvic surgery.Methods 100 patients scheduled for pelvic surgery were randomly divided into group A,B,C and D(25 in each group)with double blind method.The groups were injected with Ropivacaine 15.0 mg(group A),17.5 mg(group B),20.0 mg(group C),22.5 mg(group D)respectively after puncture in the cavitas subarachnoidealis in L2~3intervertebral space.The sensation plane and the degree of lower limb... |
| |
| Keywords: | Cavitas subarachnoidealis Ropivacaine Dose-effect relationship drug |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
