| 铁超负荷在非酒精性脂肪性肝炎发病中的作用 |
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| 引用本文： | 谭鹏. 铁超负荷在非酒精性脂肪性肝炎发病中的作用[J]. 山东医学高等专科学校学报, 2011, 0(4): 241-243 |
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| 作者姓名： | 谭鹏 |
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| 作者单位： | 山东医学高等专科学校; |
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| 摘 要： | 目的探讨铁超负荷在非酒精性脂肪性肝炎发病中的作用。方法将36只SD健康雄性大鼠随机分为正常对照组、模型对照组、高铁模型组。实验的第12周末处死大鼠，检测血清胆固醇（TC）、甘油三酯（TG）、转氨酶（ALT、AST），观察肝匀浆铁含量和肝组织病理学改变的特点。结果模型对照组各项指标较正常对照组明显升高；高铁模型组较模型对照组明显升高。肝脏病理学切片示：模型对照组和高铁模型组均可见到脂肪变性和炎细胞浸润。高铁模型组炎症活动计分明显高于模型对照组。结论铁超负荷在非酒精性脂肪性肝炎发生过程中起到重要作用。
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| 关 键 词： | 铁超负荷 非酒精性脂肪性肝炎 血脂 |
ROLE OF IRON OVERLOAD IN THE PATHOGENESIS OF NON-ALCOHOLIC FATTY LIVER DISEASE |
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| TAN Peng. ROLE OF IRON OVERLOAD IN THE PATHOGENESIS OF NON-ALCOHOLIC FATTY LIVER DISEASE[J]. Journal of Shandong Medical College, 2011, 0(4): 241-243 |
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| Authors: | TAN Peng |
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| Affiliation: | TAN Peng(Shandong Medical College,Linyi,China 276000) |
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| Abstract: | Objective To explore the role of iron overload in non-alcoholic stetohepatitis(NASH) progression.Methods 36 SD male rats were randomly divided into 3 groups: the normal control group,the model control group,and the iron overload model group.The rats were used to examine serum cholesterol(TG),triglyceride(TC),transaminase,hepatic homogenate iron content and the liver tissue disease changes in the characteristics of science.Results Compared to the normal control group,serum TG,TC,ALT,AST and Liver homogenate ... |
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| Keywords: | Iron overload Non-alcoholic steatohepatitis Blood fat |
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