Stepwise overexpression of p63, p53, and cytokeratin 14 during progression of esophageal squamous intraepithelial neoplasia: useful immunohistochemical markers for differential diagnosis |
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| Authors: | Hidenae Nakayama Hiroyuki Mitomi Abdukadir Imamhasan Shiro Uchida Natsumi Tomita Yoshiaki Kajiyama Takashi Yao Sumio Watanabe |
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| Affiliation: | (1) Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan;(2) Department of Human Pathology, Juntendo University School of Medicine, Motomachi building 3F, Hongo 1-1-19, Bunkyo-ku, Tokyo 113-0033, Japan;(3) Department of Surgery, Juntendo University School of Medicine, Tokyo, Japan; |
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| Abstract: | Background Esophageal squamous intraepithelial neoplasia (ESIN) as a precursor for invasive carcinoma is classified into low-grade IN (LIN) and high-grade IN (HIN), the latter including carcinoma in situ (CIS). Increasing grades of ESIN are associated with increasing risk of invasive carcinoma, but differentiation among LIN, HIN, and CIS is subjective and challenging. As p63, a member of the p53 family, is known to regulate differentiation and proliferation in epithelial progenitor cells, its expression, along with that of cytokeratin (CK) 14 (basal squamous marker) and Ki-67 (proliferation marker), might be of diagnostic assistance. |
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