| 偏头痛与一氧化氮 |
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| 引用本文： | 王贺波 于生元. 偏头痛与一氧化氮[J]. 中国疼痛医学杂志, 2001, 7(3): 169-172 |
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| 作者姓名： | 王贺波 于生元 |
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| 作者单位： | 解放军总医院神经内科,北京,100853 |
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| 摘 要： | 偏头痛发病机制的研究虽然取得了很大的进展，但至今尚无定论。近年来提出的三叉神经血管学说可以很好的解释偏头痛的各种临床表现，但也未能完全阐明其发病机制。一种活性极强的小分子一氧化氮，可能通过扩张脑血管、介导血管周围神经源性炎症、易化伤害觉冲动的中枢传递参与偏头痛的病理生理过程。
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| 关 键 词： | 偏头痛 一氧化氮 一氧化氮合酶 硝酸甘油 |
MIGRAINE AND NITRIC OXIDE |
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| WANG He-Bo,YU Sheng-Yuan Dept. of Neurology,Chinese PLA General Hospital,Beijing. MIGRAINE AND NITRIC OXIDE[J]. Chinese Journal of Pain Medicine, 2001, 7(3): 169-172 |
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| Authors: | WANG He-Bo YU Sheng-Yuan Dept. of Neurology Chinese PLA General Hospital Beijing |
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| Abstract: | The pathogenesis of migraine is unclear, although considerable progress has been made in recent years. While the trigeminovascular hypothesis can delineate all the symptoms of migraine, it failed to elucidate the essential pathophysiology of migraine. Nitric oxide, a highly active small molecule, may be involved in the pathogenesis of migraine through relaxing the cerebral blood vessel, mediating perivascular neurogenic inflammation and facilitating the transmission of nociceptive information. |
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| Keywords: | Migraine Nitric oxide Nitric oxide synthase Nitrioglycerin |
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