食管癌全程加速超分割放疗的临床研究

目的 :评价全程加速超分割放射治疗食管癌的疗效。方法 :98例食管鳞癌病例随机分为 2个组 :①常规分割组 (CF) 5 0例 ,方法为每次 1 8～ 2 0Gy ,5次 /周 ,总剂量 60 0 0～ 70 0 0cGy ,6～ 7周完成 ;②全程加速超分割组 (WCAHF) 48例 ,方法为 1 5Gy/次 ,2次 /d ,间隔 6h以上 ,总剂量 5 4Gy ,3 5周完成。结果 :CF组和WCAHF组的 1、3、5年生存率分别为 46%、2 0 %、12 %和 70 8%、3 9 6%、2 9 2 % ,全程加速超分割组明显优于常规组 ,2个组差异有显著性 (P <0 0 5 ) ;而放射治疗副反应和并发症 2个组差异无显著性意义 (P >0 0 5 )。结论 :全程加速超分割放射治疗能明显提高食管癌患者的长期生存率 ,不增加放射治疗副反应及并发症。

Accelerated fractionation radiotherapy for esophageal carcinoma

Objective: To evaluate the effect of accelerated fractionation radiation therapy for esophageal carcinoma.Methods: From October 1990 to May 1992,98 patients with histologically proven squamous cell carcinoma of esophagus were treated either by conventional radiotherapy at 180～200 cGy per day 5 times a week to a total dose of 6000～7000 cGy for 6～7 weeks or by accelerated fractional regime consisting of 150 cGy twice a day with an interval of 6 hours between fractions to a total dose of 5400 cGy/3 5 weeks.The same cobalt 60 teletherapy machine was used in all the patients.Results: The 1 ,3 and 5 year survival rates of patients were 46% (23/50),20%(10/50),12%(6/50) in conventional radiotherapy group,and 70.8%(34/48),39.6%(14/48),29.2%(14/48) ( P <0.05) in accelerated fractional radiotherapy group respectively.There was no significant defference found in clinical symptoms between these two groups.Conclusion: The preliminary results from our study has shown that accelerated fractionation schedule for radiotherapy of esophageal carcinoma can give better survival than that of conventional radiotherapy with no increase of untoward radioreaction and complications.