Age dependence of skin autofluorescence |
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Authors: | A I Deev E V Kozhukhova A Yu Tyurin-Kuz'min Yu A Vladimirov |
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Institution: | (1) Department of Biophysics, Russian State Medical University, Moscow;(2) P. P. Shirshov Institute of Oceanology, Russian Academy of Sciences, Moscow |
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Abstract: | The nontryptophane intrinsic fluorescence of finger pad skin was studied in men aged 20–70 years in order to evaluate the
possibility of using this parameter as a biomarker of aging. Linear correlation coefficients (r) between the fluorescence intensity and age varied from 0.50 to 0.66 for various skin sites. Age dependence of the mean value
of fluorescence (F) measured on 4 fingers can be approximated by a second-degree polynomial:F=2.82−0.083T+0.0014T
2 (r
1=0.64,r
2=0.71), whereT is chronological age in years. The proposed measurement of skin autofluorescence is a simple, noninvasive, rapid test for
evaluating the aging of the skin in subjects over 40 with a high age-related determination (r
2=0.5).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 351–353, March, 1999 |
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Keywords: | skin fluorescence aging lipofuscin biological age |
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