清肝活血方治疗酒精性肝病的临床研究

目的研究清肝活血方治疗酒精性肝病的临床疗效。方法以小柴胡冲剂和一般治疗为对照，观察清肝活血方对酒精性肝病患者症状、体征、肝功能、血脂、肝纤维化标志物、细胞因子、脂质过氧化和B超等的改善作用。结果清肝活血方对食欲减退、恶心、呕吐、黄疸的改善作用优于对照组，对ALT、AST、TG的作用优于各对照组，对GGT、VLDL的作用优于一般治疗组，并可降低肝纤维化标志物、细胞因子水平，抗肝脏脂质过氧化损伤，较明显改善脂肪肝程度，总体疗效优于一般治疗组和小柴胡冲剂组。结论清肝活血方对酒精性肝病有明显治疗作用，而抗脂质过氧化，稳定肝细胞膜，纠正肝内脂质代谢紊乱，调节免疫功能，抗肝纤维化，促进酒精的肝内代谢作用可能是其作用机制。

Clinical study on treatment of alcoholic liver disease by Qinggan Huoxue Recipe

ObjectiveTo study the effect of Qingga n Huoxue Recipe on alcoholic liver disease(ALD). Methods Effects were observed of Qinggan Huoxue Recipe on the symptoms, physical signs, liver function, blood lipid, markers of liver fibrosis, cytokine and ultrasonogr am of ALD patients; the control groups were treated with Xiao Chaihu Decoction o r general supportive treatment. ResultsThe effects of Qinggan Huoxue Recipe were better than that of the other treatments on anorexia, nausea, vomiting, jaundice, ALT, AST and TG; the effects of Qinggan Huoxue Reci pe on GGT and VLDL were better than that of the general supportive treatment. Qi nggan Huoxue Recipe could decrease the level of cytokines and markers of liver f ibrosis, its total effective rate was better than that of Xiao Chaihu Decoction and general supportive treatment. ConclusionQinggan Hu oxue Recipe could prevent and cure ALD markedly, its mechanism might be: resisti ng lipid peroxidation, stabilizing the membrane of the hepatocytes, rectifying t he disturbance of liver lipid metabolism, adjusting the immune function, anti-fi brosis, and promoting the metabolism of ethanol in the liver.