| 蓝斑内注射催产素对痛阈和吗啡镇痛的影响 |
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| 引用本文： | 胡明 由振东. 蓝斑内注射催产素对痛阈和吗啡镇痛的影响[J]. 第二军医大学学报, 1993, 14(6): 527-530 |
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| 作者姓名： | 胡明 由振东 |
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| 作者单位： | 第二军医大学海军医学系，第二军医大学神经生物学教研室，第二军医大学神经生物学教研室，第二军医大学神经生物学教研室 88级学员 200433，200433，200433，200433 |
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| 摘 要： | 作者用核团内微量注射和行为测痛法，研究了大鼠蓝斑（ＬＣ）内注射催产素（ＯＴ）或催产素抗血清（ＡＯＴＳ）对痛阈和吗啡镇痛的影响。结果表明蓝斑内注射ＯＴ可 使大鼠痛阈（ＰＴ）明显提高，且镇痛作用随ＯＴ的剂量增加而增强；而注射ＡＯＴＳ则使痛阈降低。蓝斑内注射催产素可加强皮下注射吗啡的镇痛作用，而注射ＡＯＴＳ则对吗啡镇痛作用有拮抗作用。提示ＯＴ的镇痛和对吗啡镇痛的协同作用可能与蓝斑有密切关系。
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| 关 键 词： | 催产素 蓝斑 吗啡 止痛 |
Effect of Oxytocin Injection into Locus Ceruleus on the Pain Threshold and Morphine Analgesia |
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| Hu Ming,You Zhemlong,Lu Yongfeng,Song Chaoyou. Effect of Oxytocin Injection into Locus Ceruleus on the Pain Threshold and Morphine Analgesia[J]. Former Academic Journal of Second Military Medical University, 1993, 14(6): 527-530 |
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| Authors: | Hu Ming You Zhemlong Lu Yongfeng Song Chaoyou |
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| Abstract: | The microinjection of brain nuclei and potassium iontophresis induced tail flick were used to investigate the effect of injecting oxytocin (OT) or anti-oxytocin serum (AOTS) into locus ceruleus (LC) on the pain threshold (PT) and morphine analgesia. The result showed that OT injection into LC could enhance PT, while ATOS injection could reduce PT. The OT injection could strengthen morphine analgesia, but AOTS injection could antagonize this action. These results suggest that the OT analgesia and OT-enhanced morphine analgesia were related with the locus ceruleus. |
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| Keywords: | oxytocm anti-oxytocin serum locus ceruleus morphine pain threshold animal rats |
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