Progression of a myelodysplastic syndrome to pre-B acute lymphoblastic leukemia: a case report and cell lineage study |
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| Authors: | E Abruzzese D Buss R Rainer M J Pettenati P N Rao |
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| Institution: | (1) Department of Pediatrics, Section of Medical Genetics, Bowman Gray School of Medicine, Medical Center Blvd., Winston Salem, NC 27157–1076, USA, US;(2) Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA, US;(3) Universita' degli Studi di Roma, Tor Vergata, Cattedra di Ematologia, Rome, Italy, IT |
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| Abstract: | The evolution of acute lymphoblastic leukemia from a myelodysplastic syndrome is a very uncommon event. We describe a 46-year-old
man in whom refractory anemia with excess blasts (RAEB) evolved to a pre-B acute lymphocytic leukemia. Trisomy 8 was one of
the cytogenetic abnormalities in the dysplastic clone and was detected in both peripheral blood and bone marrow smears of
interphase cells by the fluorescence in situ hybridization (FISH) technique. Using a chromosome 8 centromeric specific DNA
probe we identified the trisomy 8 to be present in lymphoblasts, erythroid precursors, myeloblasts, promyelocytes, myelocytes,
metamyelocytes, granulocytes, and monocytes. Our case supports the hypothesis that in MDS the pluripotent precursor cell is
affected, and we examine the potential role of FISH for the study and follow-up of some hematological diseases.
Received: 9 October 1995 / Accepted: 21 December 1996 |
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| Keywords: | Lymphoblastic leukemia Myelodysplastic syndrome Fluorescence in situ hybridization |
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