Neuropathophysiology of functional gastrointestinal disorders |
| |
Authors: | Wood Jackie D |
| |
Affiliation: | Department of Physiology and Cell Biology,and Internal Medicine, The Ohio State University, College of Medicine, Columbus, Ohio 43210-1218, United States |
| |
Abstract: | The investigative evidence and emerging concepts in neurogastroenterology implicate dysfunctions at the levels of the enteric and central nervous systems as underlying causes of the prominent symptoms of many of the functional gastrointestinal disorders. Neurogastroenterological research aims for improved understanding of the physiology and pathophysiology of the digestive subsystems from which the arrays of functional symptoms emerge. The key subsystems for defecation-related symptoms and visceral hyper- sensitivity are the intestinal secretory glands, the musculature and the nervous system that controls and integrates their activity. Abdominal pain and discomfort arising from these systems adds the dimension of sensory neurophysiology. This review details current concepts for the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication and the brain-gut axis. |
| |
Keywords: | Neurogastroenterology Visceral pain Diarrhea Irritable bowel syndrome Constipation Stress Enteritis Enteric nervous system Neuroimmune communication Mast cells |
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录! |
|