孕妇血清中可溶性endoglin水平与特发性胎儿生长受限的关系

目的 探讨血压正常孕妇血清中可溶性Eng水平与特发性胎儿生长受限（FGR）发生的相关性.方法 收集我院2008年11月至2009年11月分娩FGR的孕妇13例为FGR组,选择同期住院分娩的健康孕妇15例为对照组,采用酶联免疫吸附试验检测2组孕妇血清中可溶性Eng水平,分析血清中可溶性Eng水平与FGR发生的相关性并将血清中可溶性Eng水平与胎儿出生体质量作直线回归分析.结果 FGR组孕妇血清中可溶性Eng的水平为（20.0±4.0）μg/L,高于对照组的（4.46±1.71）μg/L,2组比较,差异有统计学意义（t=13.7,P＜0.05）;FGR组孕妇血清中可溶性Eng水平与胎儿出生体质量有负相关关系（r=-0.79,P＜0.05）,而对照组无明显相关性（r=0.07,P＞0.05）.结论 孕妇血清中可溶性Eng水平升高可能与FGR的发生有独立的相关性,并与胎儿出生体质量呈负相关关系.

Relation between maternal soluble endoglin and fetal growth restriction with unclear etiologies

Objective To determine whether maternal sEng is altered in normotensive pregnancies complicated with fetal growth restriction with unclear etiologies.Methods From Nov 2008 to Nov 2009, 13 women who delivered fetal growth restriction in the second hospital of TianJin Medical University were collected as FGR group.15 healthy pregnant women during the same period were enrolled as the control group.Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum concentrations of sEng in these women.Linear regression analysis between sEng level and fetal birth weight was made.Results Serum sEng level of FGR group (20.0 ± 4.0) μg/L was higher than that of control group(4.46 ± 1.71) μg/L.(t = 13.7, P ＜ 0.05) There was a negative relation between serum sEng level and fetal birth weight in FGR group(r = -0.79, P ＜0.05) but not in control group.(r =0.07, P ＞ 0.05).Conclusions The increased peripheral serum sEng level may contribute to the pathogenesis of FGR independently.There was a negative relation between maternal serum sEng level and fetal birth weight.