细胞因子与2型糖尿病胰岛素抵抗的相关性研究

目的研究2型糖尿病及胰岛素抵抗患者白细胞介素6（IL-6）、IL-8、肿瘤坏死因子仪（TNF—α）及C反应蛋白（CRP）的变化，分析细胞因子与糖尿病及胰岛素抵抗的相关性。方法125例2型糖尿病患者其中胰岛素抵抗者80例为胰岛素抵抗组，非胰岛素抵抗者45例为非胰岛素抵抗组，40例健康体检者为对照组，采用酶联免疫吸附法测定3组的IL-6、IL-8、TNF-α，并同时测定空腹血糖、糖化血红蛋白、空腹胰岛素及空腹C肽水平，分析各指标与细胞因子的相关性。结果与正常对照组比较；2型糖尿病组血清细胞因子的含量均明显增高（P〈0．05）；胰岛素抵抗组的IL-6、TNF-α、CRP分别为（91．09±22．25）ng／L、（69．51±32．37）ng／L、（0．75±0．11）ng／L与非胰岛素抵抗组[分别为（77．09±22．20）ng/L、（54．87±13．23）ng/L、（0．43±0．09）ng／L]比较差异有统计学意义（P〈0．05）。结论2型糖尿病患者存在着细胞因子的过度激活，并与胰岛素抵抗密切相关，细胞因子在2型糖尿病及胰岛素抵抗的发生发展中起着重要的作用。

Cytokines and type 2 diabetes insulin resistance

Objective To study on the changes of the IL-6、IL-8、TNF-α、CRP in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods (1) To assay the serum level of cytokines in 125 cases with type 2 diabetes mellitus(T2DM) and 40 normal controls. (2)To measure the level of fasting plasma glucose (FPG), hemoglobin A1c (HBA1c), fasting insulin (FINS), fasting C-peptide (FCP). (3)To analyze the relation of the level of FPG、HBA1c、FINS、FCP and cytokines. Results (1)The serum levels of cytokines in T2DM group were significantly higher than in control groups, IL-6、CRP、TNF-α in T2DM group with insulin resistance were significantly increase than in T2DM group without insulin resistance; (2)There was significantly positively correlation between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM, which is significantly correlated with insulin resistance. Cyto-kines plays an important role in the occurrence and development of T2DM and insulin resistance.