腮腺多形性腺瘤生物学行为相关因素的研究

目的 研究腮腺多形性腺瘤的局部生长方式及其相关因素。方法 通过观察97例原发腮腺多形性腺瘤的组织切片,了解包膜受累发生率以及包膜外浸润的发生率及扩展范围,并通过肿瘤组织类型、各成分含量、体积、病程等与包膜浸润状况的相关关系的研究,探讨腮腺多形性腺瘤的局部生长方式及其相关因素。结果 上皮成分为主型伴细胞增生活跃者较黏液样成分为主、细胞增生不活跃型的包膜更易浸润或不完整。随着上皮成分的增加或黏液样成分的减少和病程的延长,包膜浸润或不完整的发生率增加。结论 腮腺多形性腺瘤的局部生长方式与其组织学类型、形态,各成分的相对含量及病程有相关性。

Study of the relative factors of the biological behavior of pleomorphic adenoma in parotid

Objective To study the growth way of parotid pleomorphic adenoma and the relative factors. Methods The histological slides of 97 cases of the primary parotid pleomorphic adenoma were examined for the state of intra-capsule infiltration and extra-infiltration . The relative relationslips between the infiltration state and the histological type, relative amount of various components, size and course of the tumor were analysed to investigate the growth way and relative factors. Results 1. There were more chances to develop infiltration of tumor in which the major content was epithelium. The tumor was severer with the increasing of epithelium, and decreasing of mucous content and elongation of course of the disease. 2. The limitation of the extra-envelop infiltration and budding was 0.085 -0.210 mm,so, the boundary of partial parotidectomy should be away from the 1 cm envelop. Conclusion The growth way of parotid pleomorphic adenoma is related to the histological types and characters, relative amount of various components and the course of the tumor