Serotypic characterization of outer capsid spike protein VP4 of vervet monkey rotavirus SA11 strain |
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Authors: | Y Hoshino R W Jones A Z Kapikian |
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Institution: | (1) Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A., US |
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Abstract: | Summary. The vervet monkey rotavirus SA11, a prototype strain of group A rotaviruses, has been shown to possess VP7 serotype 3 specificity
but its neutralization specificity with regard to the other outer capsid protein VP4 has not been elucidated. We thus determined
its VP4 specificity by two-way cross-neutralization with guinea pig antiserum prepared with a single gene substitution reassortant
that had only the VP4-encoding gene from the simian rotavirus SA11 strain and remaining ten genes from human rotavirus DS-1
strain (G serotype 2). The SA11 VP4 was related antigenically in a one-way fashion to rhesus monkey rotavirus MMU18006 VP4
(a P5B strain) and marginally to human and canine rotavirus VP4s with P serotype 5A specificity. In addition, the SA11 VP4
was shown to be distinct antigenically from those of other known P serotypes (1–4, and 6–11) as well as those of uncharacterized
equine, lapine, and avian rotavirus strains. The SA11 VP4 is thus proposed for classification as a P5B serotype.
Received September 2, 1997 Accepted January 8, 1998 |
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