颧部褐青色痣与性激素相关性的研究

目的:探讨颧部褐青色痣（NFZ）患者血清性激素水平及皮损性激素受体与NFZ发病的相关性。方法: 采用免疫组化法检测雌激素受体（ER）、孕激素受体（PR）及雄激素受体（AR）在10例NFZ及蓝痣石蜡标本上的表达，同时对30例女性NFZ患者采用放射免疫法检测血清性激素（FSH 、P、 E2 、T、LH 及PRL）的水平,并将其结果与健康女性血清性激素水平加以比较。结果:NFZ皮损真皮黑素细胞免疫组化染色有5例AR阳性，ER和PR均为阴性，NFZ患者与健康人比较,血清E2、P、T、FSH、LH、PRL差异无显著性（p>0.05）。结论:NFZ的发病与性激素E2、P、T、FSH、LH、PRL水平无关，但其黑素细胞有雄激素受体。

Relationship of nevus fuscoceruleus zygomaticus with sexual hormones

Objective: To research on the possible mechanism of naevus fuscoceruleus zygomaticus (NFZ). Methods: The receptors of sexual hormones on the dermal melanocytes were determined by immunohistochemistry staining in skin biopsy paraffin specimens from 10 patients with NFZ and blue nevus, and the serum sexual hormones(FSH ,P,E2 ,T,LH and PRL) of 30 female patients with NFZ and 30 healthy women were examined by radioimmunoassay in the specified period. Results: The estrogen receptor(ER) and progestin receptor (PR) were negative in 10 cases. androgen receptor(AR)was positive in 5 cases. There are no statistical difference in the level of serum sexual hormones between the NFZ patients and the control. Conclusion: This study shows that there may be no relationship between the level of serum sexual hormones and NFZ（p>0.05）, But some dermal melanocytes in NFZ have androgen receptor(AR).