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CTX-M ��-Lactamase Production and Virulence of Escherichia coli K1 |
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| Authors: | Damien Dubois Nemani V. Prasadarao Rahul Mittal Laurent Bret Marie Roujou-Gris Richard Bonnet |
| Affiliation: | University of Auvergne, Clermont-Ferrand, France (D. Dubois, R. Bonnet);Teaching Hospital, Clermont-Ferrand (D. Dubois, R. Bonnet);Childrens Hospital, Los Angeles, California, USA (N.V. Prasadarao, R. Mittal);University of Southern California, Los Angeles (N.V. Prasadarao);La Source Hospital, Orléans, France (L. Bret, M. Roujou-Gris) |
| Abstract: | We report a patient with neonatal meningitis caused by a CTX-M-1–producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome. |
| Keywords: | Escherichia coli CTX-M extended-spectrum β-lactamase antimicrobial resistance virulence meningitis neonatal bacteria dispatch |