| 刺囊毛霉对天麻素的生物转化研究 |
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| 引用本文： | 占纪勋 郭洪祝 戴均贵 张元兴 果德安. 刺囊毛霉对天麻素的生物转化研究[J]. 中国药学, 2001, 10(4): 187-189 |
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| 作者姓名： | 占纪勋 郭洪祝 戴均贵 张元兴 果德安 |
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| 作者单位： | [1]北京大学药学院天然药物及仿生药物国家重点实验室，北京100083 [2]华东理工大学生物反应器工程国家重点实验室，上海200237 |
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| 摘 要： | 利用刺囊毛霉(Mucor spinosus)3．3450的培养液对天麻素进行生物转化，得到其酶水解产物甙元对羟基苯甲醇，转化率接近100％。通过无细胞抽提液对底物转化的研究，证明催化该反应的酶为组成酶、胞外酶。
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| 关 键 词： | 天麻素 生物转化 细胞 研究 反应 培养液 毛霉 苯甲醇 转化率 抽提 |
Biotransformation of Gastrodin by Mucor spinosus |
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| Zhan Jixun,,Guo Hongzhu,Dai Jungui,Zhang Yuanxing and Guo Dean. Biotransformation of Gastrodin by Mucor spinosus[J]. Journal of Chinese Pharmaceutical Sciences, 2001, 10(4): 187-189 |
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| Authors: | Zhan Jixun Guo Hongzhu Dai Jungui Zhang Yuanxing Guo Dean |
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| Affiliation: | Zhan Jixun1,2,Guo Hongzhu1,Dai Jungui1,Zhang Yuanxing2 and Guo Dean1* 1. The State Key Laboratory of Natural and Biominetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100083, 2. The State Key Laboratory of Bioreactor Engineer |
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| Abstract: | Microbial transformation of gastrodin by Mucor spinosus strain 3.3450, resulted in a product with a transformation rate close to 100 per cent. This product was identified as p-hydroxy benzyl alcohol on the basis of its 1H, 13C NMR and EI-MS spectral data. It could be inferred that the enzyme responsible for the biotransforma-tion reaction was a kind of extracellular and constitutive enzyme since the transformation reaction of the substrate could be carried out in cell free extracts of the fermentation broth of the Mucor spinosus. |
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| Keywords: | Mucor spinosus Biotransformation Gastrodin p-Hydroxy benzyl alcohol |
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