阿立哌唑对舒必利所致高催乳素血症的影响

目的 探讨阿立哌唑对舒必利所致高催乳素血症的影响及安全性.方法 对61例服用舒必利6周后的精神分裂症患者,随机分为治疗组31例,对照组30例.治疗组在服用原药的基础上,每天加用阿立哌唑10 mg,对照组维持以前的药物治疗.服用舒必利治疗第6周及第9周末分别测定患者血清催乳素水平,并进行比较.同时用不良反应量表（TESS）评定不良反应.结果 经阿立哌唑治疗后,治疗组患者血清催乳素水平明显下降（P<0.01）,对照组血清催乳素水平无明显变化.两组TESS评分差异无显著性（P>0.05）.结论 阿立哌唑对舒必利所致高催乳素血症有一定的治疗作用,并且相对安全.

Effect of Aripiprazole on the Hyperprolactinernia Caused by Sulpiride in the Treatment of Patients with Schizophrenia——A Clinical Observation

Objective To probe into the effect of aripiprazole on the hyperprolactinemia caused by sulpiride in the treatment of schizophrenia. Methods 61 patients with schizophrenia who had been treated with sulpiride for 6 weeks prior to the study were randomly divided into 2 groups : the trial group(n=31) and control group(n=30).On the basis of the sulpiride treatment,patients of the trial group were given each additionally 10 mg of aripiprazole PO,q.d..The sulpiride treatment in patients of the control group continued with no extra management.At the end of the 6th and 9th week of the sulpiride treatment,serum prolactin concentrations were assayed in patients of both groups.Adverse reactions were assessed with Treatment Emergent Symptom Scale(TESS). Results After 3 weeks of aripiprazole treatment,the serum prolactin level in patients of the trial group were significantly lowered(P<0.01) while those in patients of the control group who received no additional treatment remained high.The difference between the scales of TESS in patients of the 2 groups was not significant(P>0.05). Conclusion Aripiprazole was shown to exert definite therapeutic effect on the hyperprolactinemia caused by sulpiride and adverse reactions were not common.