Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum |
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Authors: | Wu Chien-Chang Yen Ming-Hong Yang Shyh-Chyun Lin Chun-Nan |
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Institution: | School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China. |
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Abstract: | A new phloroglucinol, hyperielliptone HA (1/1a), a new spirophloroglucinol possessing an unprecedented skeleton, hyperielliptone HB (2/2a), and two new xanthonolignoids, hyperielliptones HC (3) and HD (4), were isolated from the heartwood of Hypericum geminiflorum. Compounds 1/1a and 2/2a were obtained as tautomeric pairs. The structures and relative configurations of these compounds were elucidated by spectroscopic methods. In biological testing, compound 2/ 2a revealed significant inhibition of oxidative DNA damage and an inhibitory effect on xanthine oxidase. |
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