幽门螺杆菌感染与儿童过敏性紫癜的关系

目的探讨幽门螺杆菌感染(Hp)与儿童过敏性紫癜(HSP)的关系,寻求HSP的病因治疗。方法检测HSP特别是腹型HSP患儿及正常无症状儿童血Hp抗体(Hp-IgG)的阳性率;通过快速尿素酶的方法检测腹型HSP患儿的胃黏膜Hp感染发生率;将Hp感染相关的HSP患儿随机分为2组,分别用根除Hp治疗加常规治疗和单用常规治疗,比较两组复发率。结果HSP患儿150例,特别是90例腹型紫癜患儿Hp感染率明显高于正常儿童,且与腹部症状严重程度呈正相关;对于Hp感染相关的HSP患儿加入根除Hp三联治疗2周可减少HSP复发。结论Hp感染可能是儿童HSP的病因之一,根除Hp治疗可减少HSP的复发。

Relationship between Helicobacter Pylori Infection and Henoch-Schonlein Purpura in Children

Objective To investigate the relationship between helicobacter pylori(Hp) infection and Henoch-Schonlein purpura(HSP) in children and find out the etiological treatment for HSP.Methods Positive rate of Hp-IgG between normal children and children with HSP were compared.Infection of Hp was detected by rapid urease test,and relationship between infection of Hp and clinical symptom in Henoch purpura was analyzed.Children with HSP were randomly divided into two groups and were respectively treated with Hp eradication therapy together with conventional therapy and conventional therapy only.The recurrence rates were compared.Results The infection rate in 150 children with HSP,especially the 90 children with Henoch purpura was significantly higher than that in normal children,and it was in positive correlation with abdominal symptom.Hp infection with triplex therapy for 2 weeks in HSP could reduce the recurrence of HSP.Conclusions Hp infection may be one of the reasons of HSP in children,and is related with Henoch purpura.Eradication of Hp can reduce recurrence of HSP.