Mechanism research on combination of decoction for reinforcing lung Qi and argon helium lancet in treatment of non-small cell lung cancer |
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Authors: | Yin Zhang Shaodan Li Ke Cao Yu Feng Xiao Zhang Yueyong Xiao Jie Li |
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Institution: | 1. Department of Traditional Chinese Medicine, General Hospital of People's Liberation Army, Beijing 100853, China 2. Department of Radiology, General Hospital of People's Liberation Army, Beijing 100853, China |
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Abstract: | ObjectiveTo observe the effect of decoction for reinforcing lung Qi on T-lymphocytic function, interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in peripheral blood of patients with non-small cell lung cancer after operation with argon helium lancet in order to explore its mechanism.MethodsA total of 76 patients suffering from non-small cell lung cancer without surgical indication were randomly divided into a treatment group treated with decoction for reinforcing lung Qi and argon helium lancet and a control group treated with argon helium lancet only to observe lymphocytic proliferation, detect the percentage of positive cells in the T-lymphocyte CD28 with flow cytometry and detect the expression of IL-2 and TNF-α in peripheral blood with enzyme linked immunosorbent assay.ResultsProliferation of T-lymphocytes and expression of CD28, IL-2 and TNF-α in peripheral blood after treatment in the treatment group were more obviously strengthened than those before treatment and those in the control group (all P<0.05).ConclusionThe mechanism of using decoction for reinforcing lung Qi and argon helium lancet to treat lung cancer may be realized through promoting T-lymphocytic proliferation, up-regulating expression of CD28, IL-2 and TNF-α, and activating T-cells. |
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Keywords: | Reinforcing lung Carcinoma non-small-cell lung Molecular mechanisms of pharmacological action Argon helium lancet |
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