| 呼吸道立方形上皮细胞分泌蛋白对呼吸道合胞病毒肺部感染和免疫调节的作用 |
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| 引用本文： | 宓越群,鲍一笑,朱亚忠. 呼吸道立方形上皮细胞分泌蛋白对呼吸道合胞病毒肺部感染和免疫调节的作用[J]. 实用儿科临床杂志, 2005, 20(4): 311-312,i003 |
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| 作者姓名： | 宓越群 鲍一笑 朱亚忠 |
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| 作者单位： | 上海第二医科大学新华医院,上海儿童医学中心,上海,200127 |
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| 摘 要： | 目的探讨呼吸道立方形上皮细胞分泌蛋白(CCSP)对呼吸道合胞病毒(RSV)肺部感染和免疫调节的作用。方法以CCSP基因剔除小鼠[CCSP(-/-)]和野生型小鼠(129J,WT)为模型,通过呼吸道接种感染RSV,然后对肺部的炎症和免疫学反应进行研究。结果与WT小鼠比较,CCSP(-/-)小鼠RSV病毒的清除率下降,肺部炎症增强,Th2细胞因子和中性粒细胞趋化因子水平增加。结论CCSP缺乏可促进RSV感染所引起的肺部炎症和Th2免疫反应。
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| 关 键 词： | 呼吸道立方形上皮细胞分泌蛋白 细胞因子 炎症 基因剔除 |
| 文章编号： | 1003-515X(2005)04-0311-02 |
Effects of Clara Cell Secretary Protein in Modulating Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection |
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| MI Yue-qun,BAO Yi-xiao,ZHU Ya-zhong. Effects of Clara Cell Secretary Protein in Modulating Lung Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection[J]. Journal of Applied Clinical Pediatrics, 2005, 20(4): 311-312,i003 |
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| Authors: | MI Yue-qun BAO Yi-xiao ZHU Ya-zhong |
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| Abstract: | Objective To determine a possible role for Clara cell secretary protein(CCSP)during acute RSV infection.Method CCSP-deficient [CCSP (-/-)]and wild-type (WT) mice were intratracheally infected with RSV and the lung inflammatory response to RSV infection were assessed.Results RSV-F gene expression increased in the lungs of CCSP (-/-) mice compared to WT mice following RSV infection, consistent with increased viral persistence. Lung inflammation was significantly worsened in CCSP (-/-) mice compared to WT mice after RSV infection. Th2 cytokines and neutrophil chemokines increased in the lungs of CCSP (-/-) mice following RSV infection.Conclusion These findings suggest that lack of CCSP may promote the inflammatory and Th2 immune response to RSV infection. |
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| Keywords: | clara cell secretary protein cytokine inflammation gene knockout |
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