The ultrastructure of the dental tissues in dentinogenesis imperfecta in man |
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| Authors: | J T Wright D G Gantt |
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| Institution: | 1. Department of Pediatric Dentistry, School of Dentistry, University of Alabama in Birmingham, University Station, Birmingham, AL 35294 U.S.A.;2. Dental Research Unit, School of Dentistry, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A.;1. Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan;2. Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan;3. Section of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Science, Kyushu University, Fukuoka, 812-5852, Japan;1. Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Ultrastructural Pathology Laboratory, Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;3. Institute for Brain Research, Huazhong University of Science and Technology, Wuhan, China;4. Key Laboratory of Neurological Disease of National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;1. Unidad de Investigación, Hospital Juárez de México, México City, Mexico;2. Servicio de Reumatología, Hospital Juárez de México, Mexico City, Mexico;3. Centro Médico ABC (The American British Cowdray Medical Center), Mexico;4. Dirección de Investigación, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico;5. Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;6. Laboratorio de Biología Molecular, Instituto Nacional de Cardiología, Mexico City, Mexico;7. Departamento de Investigación en Virología y Micología, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico;8. Clínica de Enfermedades Inflamatorias Oculares, Hospital Dr. Luis Sánchez Bulnes, Asociación Para Evitar la Ceguera en México (APEC), Hospital de la Ceguera, Mexico;9. Laboratorio de Oncología Molecular, Unidad de Diferenciación Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico;1. State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, China;2. Division of Oral Biology and Medicine, School of Dentistry, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA;3. Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, 610041, China;4. Dental Implant Center, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China |
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| Abstract: | Eight primary incisors obtained from a child with dentinogenesis imperfecta (DI) type II were examined histologically using light microscopy and scanning electron microscopy. In both the DI and control teeth, large dentinal canals were observed along the midline of the crown distributed mesial-distally and coursing towards the pulp. Variably-structured mantle dentine was seen in the DI teeth ranging from tubular to virtually atubular. Enamel separation occurred at the dentine-enamel junction despite apparently normal scalloping. In the enamel, fractures occurred along accentuated striae of Retzius where ultrastructurally there was prism bending and discontinuity. The structure of DI teeth probably results from a structural or regulatory protein abnormality and irregular epithelial-mesenchymal interaction. The combined influence of these factors appears to cause variable histologic appearances and rates of tissue deposition. |
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