Fate of Human Thyroid Tissue Autotransplants |
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Authors: | Pankaj Gupta Roy Mandeep S. Saund Tej K. Thusoo Debabrata Roy Rajan Sankar |
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Affiliation: | (1) Department of Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, 110 002, India;(2) Department of Thyroidology, Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, India;(3) 5 Fell House, Abbey Way, Barrow-in-Furness, Cumbria, LA14 1BP, UK |
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Abstract: | Purpose. We conducted this study to establish whether human thyroid tissue autografts can survive and function in the absence of their native blood supply in muscle. The benefits of this potential could be incorporated in routine surgery to reduce the incidence of post-operative hypothyroidism.Methods. Fifteen patients with benign thyroid disorders, seven of whom had Graves' disease and eight, multinodular goiter (MNG), underwent modified subtotal thyroidectomy and the autotransplantation of thyroid tissue in the sternocleidomastoid muscle. About 3–5g of thyroid tissue was cut and implanted into the sternocleidomastoid muscle. Postoperative clinical assessment, thyroid function tests, and technetium scans of the neck were done to assess the function of remnant and transplanted thyroid tissue.Results. The transplanted tissue was functional in six of the eight patients with MNG and four of the seven with Graves' disease. All the patients with MNG and a functional transplant became euthyroid within 6 months postoperatively. Although the transplanted tissue was functional in four patients with Graves' disease, only one became euthyroid, while the other three required supplemental hormone therapy for postoperative hypothyroidism.Conclusions. These findings demonstrate the ability of autotransplanted thyroid tissue to survive, function, and grow in muscle. |
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Keywords: | Thyroid Autotransplantation Multinodular goiter Graves' disease Subtotal thyroidectomy |
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