| 兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用 |
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| 引用本文： | 江翰,王雪峰,王子豪,徐斌,施伟斌.兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用[J].临床肝胆病杂志,2011,27(7):746-748. |
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| 作者姓名： | 江翰 王雪峰 王子豪 徐斌 施伟斌 |
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| 作者单位： | 1. 上海交通大学附属新华医院普通外科,上海,200092
2. 上海交通大学材料学院上海200240 |
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| 基金项目： | 上海市科委纳米专项项目(0952nm03800); 上海市教委科研与创新计划(09YZ103) |
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| 摘 要： | 目的通过建立一个原发性或转移性兔肝癌模型并应用纳米微泡造影剂对肿瘤进行早期检测，探讨纳米材料在肝癌超声诊断中的应用。方法通过肿瘤组织块接种法制备兔肝癌模型并利用门静脉插管注射微泡造影剂对比增强显影。结果模型建立后检测原位成瘤率为83．3％，采用5MHz的发射频率，肝内主要血管及瘤块1min内显影得到增强。结论靶向超声纳米对比剂具有特异性和敏感性，纳米级微泡造影剂用于超声造影增强是完全可行的。
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| 关 键 词： | 疾病模型 动物 肝肿瘤 实验性 肿瘤种植 超声检查 造影剂 |
The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model |
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| JIANG Han,WANG Xue-feng,WANG Zi-hao,et al..The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model[J].Chinese Journal of Clinical Hepatology,2011,27(7):746-748. |
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| Authors: | JIANG Han WANG Xue-feng WANG Zi-hao |
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| Institution: | JIANG Han,WANG Xue-feng,WANG Zi-hao,et al.(Department of General Surgery,Xinhua Hospital Affiliated to Shanghai Jiaotong University,School of Medicine,Shanghai 200092,China) |
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| Abstract: | Objective To investigate the application of nano-scale microbubble contrast agent in hepatocarcinoma diagnosis by building a primary or metastatic liver carcinoma animal models.Methods The rabbit hepatocarcinoma model was established through vaccinating tumor tissue in liver.Tumor can be developed by injecting nano-scale microbubble contrast agent from portal vein.Results The mission success rate of model establishment is high to 83.3%,the imaging of major vascular and tumor in liver is enhanced when using ... |
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| Keywords: | disease models animal liver neoplasms experimental neoplasm seeding ultrasonography trast media |
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