Body weight changes after neurochemical manipulations of lateral amygdala: Noradrenergic and dopaminergic mechanisms |
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| Authors: | La zlo Le na rd Zolta n Hahn Zolta n Kara di |
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| Institution: | Neurophysiology Research Group of the Hungarian Academy of Sciences at the Institute of Physiology, University Medical School, Pe´cs H-7643 Hungary |
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| Abstract: | The feeding behavior of rats was studied after neurochemical lesions of lateral amygdalar terminal fields of mesolimbic dopaminergic (DA) and coerular noradrenergic (NA) systems. 6-Hydroxydopamine (6-OHDA) with or without desmethylimipramine (DMI) premedication was bilaterally injected into the lateral amygdala or periamygdaloid-piriform area. Lateral amygdalar injections of 6-OHDA resulted in hyperdipsia, hyperphagia and body weight increase with a relative decrease in amygdalar NA concentration, while 6-OHDA plus DMI treatments were followed by weight decrease and a mild decrease in DA level. When the cannulas were placed into the periamygdaloid-piriform cortex nothing but body weight increase developed. The importance of the actual balance of the two amygdalar catecholaminergic (CA) systems in feeding is discussed. |
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| Keywords: | body weight regulation food and water intake lateral amygdala periamygdaloid piriform cortex mesolimbic dopaminergic system coerular noradrenergic pathways balance of catecholamines in the amygdala 6-hydroxydopamine desmethylimipramine |
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