A case of malignant haemangioendothelioma treated with recombinant interleukin-2 |
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Authors: | S. ANSAI K. GOTO T. AOKI Y. HOZUMI K. ASO |
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Affiliation: | Department of Dermatology, Yamagata University, Faculty of Medicine, Iida-nishi, Yamagata-City, Yamagata, Japan |
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Abstract: | A case of malignant haemangioendothelioma of the scalp in an 82-year-old female treated with intralesional, intra-arterial and intravenous recombinant interleukin-2 (rIL-2) is reported. The scalp lesions disappeared after injection of 35 350 000 Japan reference units of rIL-2 and excision of the residual tumour. Immunohistochemical characterization of the cells infiltrating the lesion after rIL-2 administration revealed 30–40% CD4+ and CD8+ T lymphocytes, 20–30% macrophages and 5–10% natural killer cells. These findings are similar to those in other human cancers. Almost all of the cells in the intersticies of the lesion after rIL-2 injection expressed leucocyte function-associated antigen-1, and some of the tumour cells and the infiltrating cells around them expressed intercellular adhesion molecule-1. HLA-DR-positive cells markedly increased in number after rIL-2 administration. This report suggests that rIL-2 administration is the most effective therapy for malignant haemangioendothelioma. |
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