血浆可溶性P-选择素的检测及临床意义

目的　探讨血浆可溶性P -选择素的临床应用价值。方法　采用ELISA夹心法检测 2 38例不同肿瘤患者及 10 3例不同良恶性肝病患者血浆可溶性P -选择素的含量。并观察其变化与病情及预后的关系。结果　各种肿瘤及良性肝病患者血浆可溶性P -选择素含量均较正常人高 ;肝癌患者血浆可溶性P -选择素水平明显高于良性肝病患者 ;有肝外脏器转移肝癌患者的血浆P -选择素水平高于无肝外脏器转移肝癌患者。均有显著性差异 (P <0 .0 1或 0 .0 5 )。结论　检测良恶性疾病患者血浆可溶性P -选择素含量及观察恶性肿瘤患者血浆可溶性P -选择素水平的变化 ,对鉴别良恶性疾病以及判断恶性肿瘤的病情、预后等方面有一定的价值

Plasma soluble P- selectin and its clinical significance

Objective To study the clinical significance of plasma soluble P-selectin. Methods The concentration of plasma soluble P-selectin of 238 patients with various malignant tumours and 103 cases with various benign liver diseases was determined with ELISA methods. Results The concentration of plasma soluble P-selectin of patients with malignant tumors or with benign liver diseases were significantly higher than in the control group( P <0.01). And the concentration of patients with primary liver cancer were significantly higher than that of patients with benign liver diseases( P <0.01). And patients with metastasis out of liver were even higher than that of patients without matastasis( t=2.100, P <0.05) . Conclusion The determination of the concentration of plasma soluble P-selectin may be of valuable in the differential diagnosis and in evaluating the evolution of diseases in patients with benign and malignant liver diseases.