| 茶多酚清除氧自由基与抗脂质过氧化作用 |
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| 引用本文： | 陈小夏 何冰. 茶多酚清除氧自由基与抗脂质过氧化作用[J]. 中药材, 1998, 21(3): 141-144 |
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| 作者姓名： | 陈小夏 何冰 |
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| 作者单位： | 广东药学院，广东药学院 广州 510224，广州 510224 |
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| 摘 要： | 茶多酚对Fenton反应生成的羟自由基(·OH)具有较强的直接清除作用,其IC_(50)为919.6mg/L。茶多酚对黄嘌呤-黄嘌呤氧化酶系统产生的超氧阴离子自由基(Q_2~-)也有较强的清除作用,IC_(50)为836mg/L。茶多酚对·OH诱导的离体大鼠脑组织匀浆和线粒体产生的脂质过氧化作用有明显的抑制作用。结果提示茶多酚的抗脂质过氧化作用与其清除氧自由基作用有关。
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| 关 键 词： | 茶多酚 羟自由基 超氧阴离子自由基 脂质过氧化 |
Oxygen Free Radical Scavening Acitivity and Anti-Lipid Peroxidation of Tea Polyphenol |
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| Chen Xiaoxia,He Bing. Oxygen Free Radical Scavening Acitivity and Anti-Lipid Peroxidation of Tea Polyphenol[J]. Journal of Chinese medicinal materials, 1998, 21(3): 141-144 |
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| Authors: | Chen Xiaoxia He Bing |
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| Affiliation: | Guangdong College of Pharmacy, Guangzhou 510224. |
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| Abstract: | The oxygen free radical scavenging activity and anti-lipid peroxidation of tea polyshenol were studied in vitro. Tea polyphenol possessed significantly scavening effect on hydorxyl radical produced by Fenton recation and superoxide anion produced by xanthine-xanthine oxidase system (IC50 were 919.6mg/L and 836mg/L espectively). Tea polyphenol could significantly inhibit the lipid peroxidation of brain omogenate and cerbral mitochondrial membrane induced by hyderxyl radical. The results suggest that the anti-lipid peroxidation of tea polyphenol may be related to its scavenging effects on oxygen free radicals. |
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| Keywords: | Tea polyphenol Hydioxyl radical Superoxide anion lipid peroxidation |
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