Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents |
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Authors: | Opletalová Veronika Hartl Jirí Patel Asmita Palát Karel Buchta Vladimir |
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Institution: | Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University in Prague, Hradec Králové, Czech Republic. opletalo@faf.cuni.cz |
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Abstract: | Four series of ring substituted (E)-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones were prepared by means of modified Claisen-Schmidt condensation of acetylpyrazines with aromatic aldehydes. The structures were confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. The compounds were tested for specific biological properties and some derivatives exhibited photosynthesis-inhibiting, antifungal and antimycobacterial properties. The most pronounced effects were observed with compounds substituted with phenolic groups. Ortho-hydroxyl substituted derivatives were more potent than the corresponding para-hydroxyl substituted analogues. |
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Keywords: | Ring substituted (E)-3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones Photosynthesis-inhibiting activity Antifungal activity Antimycobacterial activity |
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