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Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles |
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| Authors: | Eleonora Colombo Davide Andrea Coppini Simone Maculan Pierfausto Seneci Benedetta Santini Filippo Testa Lucia Salvioni Giovanni Maria Vanacore Miriam Colombo Daniele Passarella |
| Affiliation: | Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano Italy.; Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milano Italy ; Dipartimento di Scienza dei Materiali, Università degli Studi di Milano Bicocca, Via Roberto Cozzi 55, 20125 Milano Italy |
| Abstract: | Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles containing varying percentages of folic acid conjugates are characterised, and their biological activity is determined.Self-assembled hetero-nanoparticles are obtained by mixing paclitaxel and folic acid conjugates. |
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