Increasing hematocrit above 28% during early resuscitative phase is not associated with decreased mortality following severe traumatic brain injury |
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Authors: | Carole Flückiger Markus Béchir Mirko Brenni Silke Ludwig Jutta Sommerfeld Silvia R. Cottini Marius Keel Reto Stocker John F. Stover |
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Affiliation: | 1. Surgical Intensive Care Medicine, University Hospital Zürich, Raemistrasse 100, 8091, Zürich, Switzerland 2. Institute of Anesthesiology, University Hospital Zürich, Zürich, Switzerland 3. Division of Trauma Surgery, University Hospital Zürich, Zürich, Switzerland
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Abstract: | Background To prevent iatrogenic damage, transfusions of red blood cells should be avoided. For this, specific and reliable transfusion triggers must be defined. To date, the optimal hematocrit during the initial operating room (OR) phase is still unclear in patients with severe traumatic brain injury (TBI). We hypothesized that hematocrit values exceeding 28%, the local hematocrit target reached by the end of the initial OR phase, resulted in more complications, increased mortality, and impaired recovery compared to patients in whom hematocrit levels did not exceed 28%. |
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