探讨宫颈上皮内瘤变的病理分级变化及其临床意义

目的 探讨宫颈上皮内癌变(cervical intraepithelial neoplasia,CIN)宫颈活检或电圈环切术(loop electrical excision procedure,LEEP)后连续病例的病理分级转化及其临床意义.方法 收集CIN活检或LEEP后连续病例的临床病理资料共计374例,对不同诊治手段和CIN病理分级转化进行对比分析.结果 经阴道镜活检,374例患者术后病理检查368例符合宫颈上皮内瘤变(CIN Ⅰ、CINⅡ、CINⅢ),6例为浸润癌.LEEP后再治疗的CIN患者中,随访发现30例再次出现宫颈病变.结论 经宫颈活检或LEEP结合病理检查能准确的诊断宫颈病变,并能较好治疗CIN.

Pathologic grade change of cervical intraepithelial neoplasia and its clinical significance

Objective To investigate the pathologic grade change and its clinical significance after the cervix biopsy or LEEP in the continual cases of cervical intraepithelial neoplasia(CIN).Methods The clinicopathological data in 374 continualcases of cervix biopsy or LEEP were collected and performed the comparative analysis on different diagnostic and treatment measures and the pathological grade changeof CIN.Results Among 374 cases of postoperative pathology examination by vaginoscopic biopsy,361 cases accorded with CIN(CINⅠ,CINⅡ,CINⅢ) and 6 cases were infiltrating cancer.Among retreated CIN patients after conization,reoccurence of cerviccal lesions occurred in 30 cases during follow up period.Conclusion The cervix biopsy or LEEP combined with pathology can accurately diagnose cervical lesions and better treat CIN.