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Interictal cerebral metabolism in partial epilepsies of neocortical origin |
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| Authors: | TR Henry WW Sutherling J Engel Jr MW Risinger MF Levesque JC Mazziotta ME Phelps |
| Institution: | a Department of Neurology, University of Michigan, Ann Arbor, MI, U.S.A. b Department of Neurology, University of California, Los Angeles, CA, U.S.A. c Department of Surgery (Neurosurgery), University of California, Los Angeles, CA, U.S.A. d Department of Radiology, University of California, Los Angeles, CA, U.S.A. e Departments of Anatomy and Cell Biology, University of California, Los Angeles, CA, U.S.A. f Laboratory of Nuclear Medicine, University of California, Los Angeles, CA, U.S.A. g Brain Research Institute, University of California, Los Angeles, CA, U.S.A. h Mincep Epilepsy Care P.A., Minneapolis, MN, U.S.A. |
| Abstract: | We performed interietal 18F]fluorodeoxyglucose positron emission tomography (FDG PET) in 24 patients with partial epilepsy of neocortical origin. Two-thirds of patients had regions of hypometabolism. The zone of intracranially recorded electrographic ictal onset was always located in a region of hypometabolism, in those with hypometabolism. Hypometabolic regions in partial epilepsies of neocortical origin were usually associated with structural imaging abnormalities. Regional hypometabolism occasionally occurred without localizing ictal scalp EEG and cerebral magnetic resonance imaging findings, however. FDG PET may be useful in directing placement of intracranial electrodes for presurgical evaluation of refractory neocortical seizures. |
| Keywords: | Partial epilepsy Neocortex Cerebral metabolism |
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