高频热消融联合TACE治疗中晚期原发性肝癌的疗效观察

目的 探讨高频热消融(HiTF)联合肝动脉化疗栓塞术(TACE)对中晚期原发性肝癌的治疗效果.方法 将经病理、影像学诊断及AFP值证实的原发性肝癌符合入选条件的患者共65例,按住院号数的单、双数随机分成两组:对照组(TACE+无水酒精消融PEI组):32例,男26例、女6例,年龄18～78(平均52岁);治疗组(TACE+HiTY组)33例,男25例、女8例,年21～79岁(平均51岁).对照组患者行TACE后2～3周给予影像导向下PEI治疗;治疗组TACE后2～3周给予影像导向下HiTT消融治疗.结果 对照组治疗32例患者,1、2、3年生存率分别为73%、56%和23%,中位生存期1.876年;治疗组33例患者1、2、3年生存率分别为87%、76%和51%,中位生存期2.134年.治疗组的生存率及生存期均显著高于对照组(P＜0.05).治疗组的介入治疗效果与死亡风险率呈显著的负相关(P＜0.05).结论 高频热消融联合TACE对中晚期原发性肝癌的治疗效果明显高于无水酒精消融(PEI)与TACE联合,可提高原发性肝癌的生存率,延长生存期.

Research of high frequency induced thermotherapy efficiency for treatment of hepatocellular carcinoma

Objective To investigate the effectiveness of high frequency induced thermotherapy in the treatment of hepatocellular carcinoma Methods We included a 65 proven cases of hepatocellular carcinoma in which the diagnosis was confirmed by pathology, radio-imaging and AFP value. The patients were randomly divided into 2 groupsby odd or even hospitalization number. A total of 32 patients were enrolled in the TACE + PEI only group and 33 patients were enrolled in the TACE + HITT therapy group. Results For the 32 patients in TACE + PEI only therapy group, the 1,2, and 3 year of survival rates were 73% , 56% , and 23% , respectively, with a median survival of 1. 876 years. For patients in the therapy group, the 1,2, and 3 year survival rates were 87% , 76% , and 51% , respectively, with a median survival of 2. 134 years. Survival rate and duration in the therapy group was significantly greater in the combination therapy group compared to the control group (P < 0. 05 ). There was a negative correlation between the effectiveness of combination therapy and the mortality risk ( P < 0. 05). Conclusion HiTT + TACE can significantly increase survival rate and extend length of survival in patients with hepatocelluar carcinoma.