X linked neonatal myotubular myopathy: one recombination detected with four polymorphic DNA markers from Xq28. |
| |
| Authors: | A E Lehesjoki E M Sankila J Miao M Somer R Salonen J Rapola A de la Chapelle |
| |
| Affiliation: | Department of Medical Genetics, University of Helsinki, Finland. |
| |
| Abstract: | A three generation family with X linked myotubular myopathy (MTM1) was studied with several polymorphic markers from the distal long arm of the X chromosome. A recombination between the disease gene and four markers (loci DXS52, DXS134, DXS15, F8C) from the Xq28 cluster was detected. A new polymorphic marker (U6.2) defining the locus DXS304 in the Xq27-28 region proximal to the Xq28 cluster did not show any recombination with MTM1. These results suggest the following order of loci in distal Xq: cen-DXS42-DXS105-(DXS304, MTM1)-(DXS52, DXS134, DXS15, F8C)-tel. |
| |
| Keywords: | |
|
|
