Synthesis and antimicrobial activity of new adamantane derivatives III |
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Authors: | Orzeszko Andrzej Kamińska Beata Starościak Bohdan J |
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Institution: | Agricultural University, Institute of Chemistry, Warsaw, Poland. |
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Abstract: | Some novel ester imides synthesised from trimellitic acid anhydride and 1-adamantanol or 2-adamantanol, were tested as antimicrobial compounds. Unfortunately, these agents showed a modest antibacterial activity (MIC > 6 microg/ml). However, a comparison of these N-substituted adamantylester imides with the series published previously, indicated that the incorporation of L-alanine and L-phenylalanine into the phthalimide moiety was the best choice regardless of the series and leads to antimicrobial activity against Staphylococcus aureus strains. |
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Keywords: | Adamantane derivatives Imides Antimicrobial activity |
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