| 海洋抗癌活性物质最新研究概况 |
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| 引用本文： | 王小兵,赵桂森. 海洋抗癌活性物质最新研究概况[J]. 药学进展, 2005, 29(7): 302-309 |
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| 作者姓名： | 王小兵 赵桂森 |
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| 作者单位： | 山东大学药学院药物化学教研室,山东,济南,250012 |
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| 摘 要： | 分类简要概述近年来源自海洋生物抗肿瘤药物的最新研究与开发,其中包括肽类、大环内酯类、生物碱类、萜类、多聚乙酰类、多烯醚类等。海洋抗癌活性物质在海洋天然产物研究中占据重要地位,大多具有新结构和新作用机制,其中许多化合物作为抗癌药物已进入临床前及临床研究阶段。
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| 关 键 词： | 海洋抗肿瘤药物 细胞调亡 细胞毒性 作用机制 |
| 文章编号： | 1001-5094(2005)07-0302-08 |
| 修稿时间： | 2005-02-01 |
Overview of Recent Progress on Marine Anticancer Active Substances |
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| WANG Xiao-bing,ZHAO Gui-sen. Overview of Recent Progress on Marine Anticancer Active Substances[J]. Progress in Pharmaceutical Sciences, 2005, 29(7): 302-309 |
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| Authors: | WANG Xiao-bing ZHAO Gui-sen |
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| Affiliation: | WANG Xiao-bing,ZHAO Gui-sen* |
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| Abstract: | The recent research and development of marine anticancer active substances were briefly summarized in classified manner, including peptides, macrolides, alkaloids, terpenes, polyketide, polyene ethers and so on. The marine anticancer active substances play important roles in the research of natural products from marine sources, which are mostly characterized by new structures and new mechanisms of action, and some of them as anticancer agents have entered preclinical or clinical trials. |
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| Keywords: | Marine anticancer agent Cell apoptosis Cytotoxicity Mechanism of action |
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