| PCNA、p53和hTERT在子宫颈病变中的表达及意义 |
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| 引用本文： | 王玉莲,方林彬,林琼燕. PCNA、p53和hTERT在子宫颈病变中的表达及意义[J]. 河北医学, 2006, 12(9): 847-849 |
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| 作者姓名： | 王玉莲 方林彬 林琼燕 |
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| 作者单位： | 广东省雷州市人民医院,广东,雷州,524200;广东医学院附属医院,广东,湛江,524001 |
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| 摘 要： | 目的:探讨PCNA、p53和hTERT在宫颈糜烂,宫颈上皮内瘤样变(CIN)及宫颈癌中的表达及临床意义。方法:采用免疫组化技术检测宫颈糜烂22例,宫颈上皮内瘤样变38例,宫颈癌20例中PCNA、p53和hTERT的表达。结果:PCNA、p53和hTERT在宫颈糜烂,宫颈上皮内瘤样变及宫颈癌中的表达有统计学差异。结论:PCNA、p53和hTERT与宫颈癌的发生发展相关,它们的异常表达为宫颈癌的诊断提供了一定的病理学依据。
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| 关 键 词： | 宫颈癌 p53 hTERT |
| 文章编号： | 1006-6233（2006）09-0847-03 |
Expression and Clinical Significance of PCNA, p53 Protein and hTERT in Cervical Lesion |
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| WANG Yu - lian, et al. Expression and Clinical Significance of PCNA, p53 Protein and hTERT in Cervical Lesion[J]. Hebei Medicine, 2006, 12(9): 847-849 |
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| Authors: | WANG Yu - lian et al |
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| Abstract: | Objective: To investigate the clinical significance and the expression of PCNA,P53 protein and hTERT in cervical lesion tissues.Method: Immunohistochemistry was used to examine the expression of PCNA,p53 protein and hTERT in 22 cervical erosion tissues and 38 cervical intraepithelial neoplasia(CIN) tissues and 20 cervical carcinoma tissues.Result: The expression of PCNA,p53 protein and hTERT showed an increasing tendency from 22 normal cervical tissues to 38 CIN tissues,then to 20 cervical carcinoma tissues.Conclusion: The expression of PCNA,p53 protein and hTERT plays an important role in the development and malignant changes of cervical carcinoma. |
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| Keywords: | Cervical carcinoma p53 hTERT |
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