Transcobalamins in the etiology of neural tube defects |
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Authors: | Per Magnus ,Erik M. Magnus,Kå re Berg |
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Affiliation: | Department of Epidemiology, National Institute of Public Health, Oslo, Norway. |
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Abstract: | In a sample of 79 pregnant women at risk offspring with neural tube defects (NTDs) and 158 controls, significantly increased median values were found for apo-transcobalamins I and II in amniotic fluid in the group at risk, thus confirming previous results. The findings may reflect a genetic disposition to NTDs associated with altered levels of apo-transcobalamins, and research on the etiology and mechanisms of NTDs should focus on these proteins. |
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Keywords: | amniotic fluid genetic predisposition neural tube defects transcobalamins |
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