青壮年冠心病危险因素的病例对照研究

目的探讨青壮年冠心病的危险因素。方法用病例-对照研究方法将确诊入院治疗的青壮年冠心病病人60人作为病例组(Ⅰ组),另将入院的非心脏病青壮年60名(Ⅱ组)和60名老年冠心病病人(Ⅲ组)作为不同的对照组,进行询问调查和辅助检查。结果单因素分析表明,Ⅰ组病人在高血压病家族史、冠心病家族史和吸烟项目上与Ⅱ组、Ⅲ组比较差异明显(P<0.05或P<0.01),OR值分别是:高血压家族史为1.42和2.07,冠心病家族史为2.17和2.68,吸烟为1.93和2.28.经Logistic回归结果显示:青壮年冠心病的主要危险因素是高血压和冠心病家族史、吸烟、高血压病史及体重指数较大,与老年冠心病人发病的危险因素确有不同。结论对于青壮年,特别是具有家族阳性病史的青壮年进行有效地控制吸烟、体重和血压对于防止青壮年冠心病具有重要的意义。

Case - control Study on Risk Factors of Premature Coronary Heart Disease

ObjectiveTo discuss risk factors of premature coronary heart dirsease.MethodsA case-control study was conducted in investigating the risk factors of coronary heart disease(CHD).Participants were divided into three groups,premature coronary heart disease(groupⅠ);premature control(groupⅡ),and elderly control groups(groupⅢ).Each group had 60 people.ResultsCompared with the groupⅡ,odds ratio(OR)of family history of CHD,cigarette smoking,hypertension were 2.17,1.93,1.42,when compared with group Ⅲ,OR of cigarette smoking,family history of CHD and hypertension were 2.28,2.68,2.07 respectively.Means of cigarette smoking each day in groupⅠwas significantly higher than that of two groups.Multiple variables analysis indicated that variables being selected into Logistic equation in former analysis were physical exercise,family history of CHD and number of cigarettes each day and in latter analysis were history of hypertension, family history of CHD and hypertension,which maybe the risk factors of premature coronary heart disease.ConclusionIt was significant to control smoking,weight and blood pressure of premature,especially those with positive family history.