小细胞肺癌手术联合化疗与单纯化疗生存期比较

目的 小细胞肺癌(SCLC)患者手术联合化疗和单纯化疗的生存期比较.方法 收集1999-2004年吉林大学第一医院胸外科37例SCLC患者,术后用依托泊甘+顺铂或卡铂方案化疗4～6个疗程.选取37例年龄、分期及肿瘤部位相仿的对照组患者,用依托泊甘+顺铂或卡铂方案化疗6个疗程.两组分别随访5年,进行生存率比较.结果 手术联合化疗组的1、3、5年总的生存率分别为72.97%、35.13%、21.62%.对照组1、3、5年总的生存率分别为54.05%、13.51%、5.41%.两组Ⅰ期SCLC生存率差异有统计学意义(P=0.01),Ⅱ和Ⅲ期差异无统计学意义(P=0.06,P=0.836).结论 手术后联合化疗对Ⅰ期的SCLC具有良好的治疗效果.

A comparative study of survival time of surgery combined with chemotherapy and non-surgical chemotherapy in SCLC

Objective To compare the survival time of surgery combine with chemotherapy with non-surgery chemotherapy in SCLC.Methods 37 SCLC post operation patients were received 4-6 cycles of chemotherapy of "etoposide + cisplatin or carboplatin".37 SCLC patients were selected be control group,whose age 、stage and site of tumor were similar to surgery combine with chemotherapy group,and received 6 cycles of chemotherapy of "etoposide + cisplatin or carboplatin".Two groups were followed up 5 year and compared with the survival time.Results The 1,3,5 year survival rate of surgery combined with chemotherapy group were 72.97%,35.13%,21.62%.The 1,3,5 year survival rate of control group were 54.05%,13.51%,5.41%.The survival rate of stageⅠ(P = 0.01) was significantly different,but stage Ⅱ(P =0.06) and stage Ⅲ (P = 0.836) were no difference between the two group of SCLC.Conclusion It was found that surgery combined with chemotherapy got satisfactory effects in stage Ⅰ SCLC.