Comparative activity of 4,4'-diaminobiphenyl (benzidine) and its terphenyl analogue, 4,4'-diaminoterphenyl, in two in vitro assays for potential carcinogenicity |
| |
Authors: | Ashby J Styles J Callander R D |
| |
Affiliation: | Imperial Chemical Industries Limited, Central Toxicology Laboratories, Macclesfield, Cheshire, UK. |
| |
Abstract: | The carcinogen 4,4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4,4'-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an understanding of the mechanism of action of benzidine as a carcinogen. |
| |
Keywords: | |
本文献已被 PubMed Oxford 等数据库收录! |
|