41例脊柱浆细胞瘤中E-cadherin的表达与临床病理特征的关系

目的 探讨脊柱浆细胞瘤中E-cadherin蛋白的表达,及其与脊柱浆细胞骨髓瘤生物学行为的关系.方法 应用免疫组织化学S-P法检测41例脊柱浆细胞瘤及14例脊柱良性单纯性骨囊肿中E-cadherin蛋白的表达.结果 41例脊柱浆细胞瘤中E-cadherin蛋白表达阳性率为46.34%,而良性骨囊肿中E-cadherin蛋白表达呈全阴性,存在统计学差异(P<0.01),脊柱浆细胞骨髓瘤中E-cadherin表达阳性组总生存率明显高于阴性组(P<0.01).本研究还发现脊柱浆细胞骨髓瘤中E-cadherin表达与轻链分型有关,未分泌型(6/9,66.7%)和κ型(4/12,66.7%)阳性率均较λ型(5/20,25%)高,且存在统计学差异(P<0.05).但E-cadherin的表达与脊柱浆细胞瘤的临床分型、免疫球蛋白分型、性别及年龄等,均无关(P>0.05).结论 提示联合检测E-cadherin和轻链分型有助于对浆细胞骨髓瘤侵袭能力的评估,对浆细胞骨髓瘤的预后判断可能具有一定的临床意义.

The expression of E-cadherin and its clinical significance in 41 spinal plasmacytoma

Objective To investigate the expression level of E-cadherin in spinal plasmacytoma and the relationship between the E-cadherin expression and the elinicopathological parameters of spinal plasmacytoma.Methods The expression of E-eadherin was detected in 41 spinal PCMs and 14 simple bone cysts by using S-P(streptavidin-perosidase) immunohistochemical staining.Results In spinal plasmacytoma,the positive expression rate of E-cadherin(46.34%) was higher than that in simple bone cyst tissues(all negative)(P< 0.01).And the expression of E-cadherin had no obvious relationship with patients age,gender,clinical or immunoglobulin classification(P > 0.05),but had relationship with the classification of light chain,the expression rate in lambda chain was lower than that in the others(P< 0.05).We also found the E-cadherin negative patients had a higher overall survival rate than those had strong E-cadherin expression(P<0.05).Conclsuion E-cadherin expressed higher in spinal PCM than in simple bone cyst tissues and its expression had relationship with the light chain classification in spinal plasmacytoma.The patients with no stain of E-cadherin maybe have a poor prognosis.