异种无机骨复合自体骨髓移植在颈椎前路融合术中的应用

目的探讨异种无机骨复合自体骨髓移植的临床应用价值. 方法 1999年1月～2002年1月将脱蛋白、脱脂的异种无机松质骨混合自体髂骨骨髓移植,用于21例颈椎前路减压融合术.治疗颈椎间盘突出症9例,外伤性颈椎骨折脱位12例.其中采用单纯移植2例,并用前路自锁钢板19例. 结果术后随访12～36个月,平均21个月,所有患者术后正侧位X线片见骨折复位和植骨位置良好,无感染等并发症.2例颈椎间盘突出症行单纯植骨者,术后6个月X线片显示植骨块塌陷,颈椎曲度回复至术前状态;其余植骨块形状无改变,无植骨块脱出,无钢板或螺钉断裂.神经功能均有不同程度恢复,术前A级10例,C级7例,D级4例.术后A级中5例未恢复,3例恢复至B级,2例恢复至C级;C级5例恢复为D级,另2例恢复为E级;D级的4例均恢复为E级. 结论异种无机骨复合自体骨髓可作为移植骨材料,用于颈椎前路融合术中,但其力学强度需要提高或并用坚强内固定.

APPLICATION OF HETEROGENOUS BONE COMBINED WITH AUTO-MARROW IN ANTERIOR CERVICAL INTERBODY FUSION

Objective To study the clinical application of heterogenous bone graft combined with auto- marrow. Methods Deproteinated and degreased heterogenous cancellous bone combined with auto-marrow was used in 21 cases of anterior cervical interbody fusion. Among them, 2 cases were treated by bone graft only, and the other 19 cases were further treated by anterior plate fixation. Results The follow-up time was 12-36 months with an average of 21 months. After operation, posteroanterior and lateral radiograph of all the cases revealed that the reduction and the position of the grafting bone were good without inflammation or other complications. After 6 months of operation, the radiograph of 2 cases of cervical disk herniation, which were treated by bone graft only, showed the bones lost their height and the curve of the cervical spine returned to the state of preoperation. For the other cases, the grafting bones remained their original figure without dislocation of the bone or fracture of the plate or the screw. The nervous function recovered variously. Before operation, 10 cases were ranked as grade A, 7 cases grade C, 4 cases grade D according to Frankel classification. After operation, in grade A cases, 5 cases did not recover, 3 cases recovered to grade B, 2 cases to grade C; in grade C cases, 5 to grade D, 2 to grade E; all of grade D 4 cases to grade E. Conclusion Heterogenous bone combined with auto-marrow can be used as grafting material in the anterior cervical interbody fusion, but its mechanical rigidity need to be improved or the fusion should be aided with rigid internal fixation.