| 大鼠视皮层硫化软骨素粘多糖降解对闪光诱发电位的影响 |
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| 引用本文： | 刘明明,秦伟,谢汉平,余延基.大鼠视皮层硫化软骨素粘多糖降解对闪光诱发电位的影响[J].第三军医大学学报,2010,32(10). |
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| 作者姓名： | 刘明明 秦伟 谢汉平 余延基 |
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| 作者单位： | 第三军医大学西南医院全军眼科中心,重庆,400038 |
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| 摘 要： | 目的在视觉发育可塑性关键期终止前后,观察软骨素酶ABC(chondroitinase ABC,ChABC)降解LongEvans大鼠视皮层硫化软骨素粘多糖(chondroitin sulfate proteoglycans,CSPGs)后闪光视觉诱发电位(flash visual evoked potential,F-VEP)的变化。方法对出生后21、35、49d正常组及同时间点ChABC酶视皮层灌注组大鼠进行F-VEP检查。结果正常组大鼠21、35、49d,F-VEP主波的潜时逐渐缩短,分别为(63.5±10.1),(50.8±6.4),(44.9±6.3)ms,P0.05],波峰值由21d的(15.7±3.8)ms增加至35d的(26.6±4.0)ms(P0.05),49d较35d稍降低。35、49dChABC酶视皮层灌注组大鼠F-VEP主波的潜时分别为(62.5±8.0),(58.4±7.6)ms,较同时间点正常组明显延长(P0.05),主波振幅两组间各时间点无明显差异(P0.05)。结论在视觉发育可塑性关键期终止前后,降解大鼠视皮层CSPGs影响了F-VEP的发育变化。
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| 关 键 词： | 硫化软骨素粘多糖 闪光视觉诱发电位 视皮层 视觉发育 |
Effect of CSPGs degradation on flash visual evoked potential in rat visual cortex |
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| Liu Mingming,Qin Wei,Xie Hanping,Yu Yanji.Effect of CSPGs degradation on flash visual evoked potential in rat visual cortex[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(10). |
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| Authors: | Liu Mingming Qin Wei Xie Hanping Yu Yanji |
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| Institution: | Liu Mingming,Qin Wei,Xie Hanping,Yu Yanji (Cneter of Ophthalmology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China) |
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| Abstract: | Objective To investigate the effects of chondroitin sulfate proteoglycans (CSPGs) degradation induced by chondroitinase ABC (ChABC) on the rat flash visual evoked potential (F-VEP) around the end of the critical period of visual development.Methods A total of 30 Long Evans rats were randomly divided into 3 groups according to their age of 14,21 and 35 d.Then in each group,5 animals served as CSPGs degradation model induced by ChABC microinjection into 5 sites of the rat cortex 750 nL (48 U/ml) for 1 site,f... |
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| Keywords: | chondroitin sulfate proteoglycans flash visual evoked potential visual cortex visual development |
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