Axonal atrophy in the painful peripheral neuropathy in AIDS |
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| Authors: | G. N. Fuller J. M. Jacobs R. J. Guiloff |
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| Affiliation: | (1) Department of Neurology, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, Black Building, Room 323, 10032 New York, NY, USA;(2) Department of Pathology, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, Black Building, Room 323, 10032 New York, NY, USA;(3) Institut de Recherches Cliniques de Montreal, 110 Avenue des Pins Ouest, H2W 1R7 Montreal, Quebec, Canada |
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| Abstract: | Summary Two patients with lymphoproliferative disorders developed peripheral neuropathy and neoplastic lymphocytic nerve infiltrates. One of these patients, with B cell small lymphocytic lymphoma, presented with a chronic axonal neuropathy. CD22+, CD5– cells were identified in the epineurium. The other patient with chronic lymphocytic leukemia of 3 years duration developed a mixed axonal and demyelinating neuropathy. CD22+ and CD5+ cells were observed in the endoneurium. While the cause of the neuropathy in these two cases is unknown, intraneural or systemic autoantibody production may have led to the development of disease.Supported by center grants from the NIH (NINCDS-NS117661) and the Muscular Dystrophy Association to Columbia University, by a grant from the Aaron Diamond Foundation, and by NIH grants CA48236 and EY06337 to Dr. Knowles. Dr. Thomas is a fellow of the Charles A. Dana Foundation and of the Muscular Dystrophy Association |
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| Keywords: | B cell small lymphocytic lymphoma B cell chronic lymphocytic leukemia Peripheral neuropathy Autoantibodies |
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