持续硬膜外阻滞分娩镇痛的激素变化对宫缩的影响

目的探讨持续硬膜外阻滞分娩镇痛的激素变化,认识分娩镇痛的规律。方法采用分娩镇痛和不采用任何镇痛技术阴道分娩的两组初产妇,比较血中前列腺素E1、前列腺素E2、皮质醇、内皮素的变化。结果在第三产程末,前列腺素E2、皮质醇及内皮素测定值下降显著,研究组与对照组之间有显著性差异。而前列腺素E1的含量虽下降,但研究组与对照组之间无显著性差异。结论在分娩镇痛后,促使子宫平滑肌收缩的激素含量下降时,会导致宫缩减弱。

Effects of uterine contraction to hormonal change of birth process of continuous epidural block anesthesia of labor

Objective:This paper discusses the effect of continuous epidural block to the birth process by studying the hormonal change during anesthesia of labor.Methods: We have chosen two groups of spontaneous labor primipara,one with anesthesia during the labor as the experimental group and one without as the control group.The change of the prostaglandin E1,E2,cortisol and endothelin between these two groups have been monitored.Results:At the end of the third stage of labor,the value of the prostaglandin E2,cortisol and endothelin decreased significantly for the experimental group while not for the control group.There is some decrease of the prostaglandin E1 for the experimental group.However,the difference between these two groups was not obvious.Conclusion:The decrease of the hormonal induced by the anesthesia of labor,which is to spur uterine smooth muscle to contract,will weaken the uterine contraction.