西藏小型猪、小猎犬与人血液流变学指标的比较研究

目的 探讨西藏小型猪、比格犬与人血液流变学指标的相互关系.方法 采集成年西藏小型猪、比格犬和人的血液样品,用全自动血液粘度计分别测定其全血粘度(WBV,高、中、低切变率)、血浆粘度、红细胞压积、血沉及血浆纤维蛋白原5项血液流变学指标.结果 (1)雄性西藏小型猪的WBV值(150、30、5、1s~(-1))和血浆纤维蛋白原含量均显著低于雌性(P<0.05,P<0.01,P<0.05,P<0.01,P<0.01);(2)雄性比格犬的WBV值(150和1 s~(-1))显著低于雌性(P<0.05);(3)男性的WBV(1s~(-1))和红细胞压积值显著高于女性(P<0.05,P<0.01),而男性的血沉值则显著低于女性(P<0.01);(4)比格犬的WBV(1 s~(-1))、血浆粘度、血沉值均显著低于西藏小型猪和人(P<0.05,P<0.01,P<0.05),而红细胞压积值和血浆纤维蛋白原含量则显著高于西藏小型猪和人(P<0.01);(5)西藏小型猪和人的各项血液流变学指标之间均不存在显著差异(P>0.05).结论 与比格犬相比,西藏小型猪的血液流变学指标更接近于人.

Abstract：

Objective To investigate the relationship of hemorheological parameters between Tibet mini-pigs,Beagle dogs and human.Methods Blood samples were collected from adult Tibet mini-pigs,Beagle dogs and human to detect such hemorheological parameters as the whole blood viscosity(WBV) (high,middle,and low shear rate),PV,HCT,ESR and Fi.Results The male Tibet mini-pigs had significantly lower WBV(150,30,5,and 1 s~(-1))and Fi than the female mini-pigs(P<0.05,0.01,0.05,0.01,and 0.01,respectively).The WBV of male Beagle dogs(150 and 1 s~(-1))was significantly lower that in than female dogs(P<0.05).The WBV of male human subjects(1 s~(-1))and HCT were significantly higher,but ESR significantly lower than those in female human subjects P<0.05,0.01 and 0.01,respectively).WBV(1 s~(-1)),PV,and ESR in Beagle dogs were significantly lower,but HCT and Fi significantly higher than those in Tibet mini-pig and human subjects(P<0.05,0.01,0.05,and 0.01,respectively).All the hemorheological parameters were similar between Tibet mini-pigs and human(P<0.05).Conclusion The hemorheological parameters of Tibet mini-pigs are closer to those of human than those of Beagle dogs.

Comparative studies of hemorheological parameters in Tibet mini-pigs,Beagle dogs and human

Objective To investigate the relationship of hemorheological parameters between Tibet mini-pigs,Beagle dogs and human.Methods Blood samples were collected from adult Tibet mini-pigs,Beagle dogs and human to detect such hemorheological parameters as the whole blood viscosity(WBV)(high,middle,and low shear rate),PV,HCT,ESR and Fi.Results The male Tibet mini-pigs had significantly lower WBV(150,30,5,and 1 s-1) and Fi than the female mini-pigs(P<0.05,0.01,0.05,0.01,and 0.01,respectively).The WBV of male Beagle ...