脆性组氨酸三联体在子宫内膜异位症的表达及意义

目的 通过观察脆性组氨酸三联体(Fhit)在子宫内膜异位症中的表达,探讨Fhit在子宫内膜异位症发病中的作用.方法 应用免疫组化SP法检测58例子宫内膜异位症(EMS)患者(包括36例卵巢子宫内膜异位症和22例子宫腺肌症)的异位内膜和在位内膜及15例子官肌瘤患者子宫内膜(对照组)中Fhit的表达情况.结果 Fhit主要表达在腺体上皮细胞的胞浆和胞膜,其表达强弱顺序为:对照组子宫内膜>EMS组在位内膜>EMS组异位内膜,EMS在位和异位内膜Fhit表达在增生期和分泌期均无显著性差异(P>0.05);EMS组在位内膜的Fhit表达在临床r-AFS分期的不同期别中均无显著性差异(P>0.05),但异位内膜的Fhit表达在不同r-AFS分期中差异显著(P<0.05);卵巢EMS组和子宫腺肌症的在位和异位内膜Fhit的表达均无显著性差异.结论 Fhit可能与子宫内膜异位症的发生、发展过程中起重要作用.

Abstract：

Objective To detect the expression of fragile histidine triad in endometriosis and investigate the pathogenesis of endometriosis.Methods Immunohistochemistry was used to examine the expression of Fhit in the eutopic and ectopic endometria of 58 patients with endometriosis and in the endometria in 15 patients with hysteromyoma.Results The intensity of Fhit expression decreased in the order of normal endometrium,eutopic endometrium in endometriosis group,and ectopic endometrium.In patients with endometriosis,Fhit expression in the emopic and ectopic endometria in proliferative phase showed no significant difference from that in secretory phase (P>0.05).Fhit expression in the ectopic endometrium showed significant difference between different r-AFS stages.MOD of ectopic endometrium in stages Ⅰ-Ⅱ was significantly higher than that in stages Ⅲ-Ⅳ(P<0.05),but Fhit expression in the eutopic endometrium showed no significant difference(P>0.05).MOD of ovarian endometriosis showed no difference with that of adenomyosis.Conclusions Fhit may play an important role in the development of endometriosis.

Expression of fragile histidine triad in endometriosis

Objective To detect the expression of fragile histidine triad in endometriosis and investigate the pathogenesis of endometriosis.Methods Immunohistochemistry was used to examine the expression of Fhit in the eutopic and ectopic endometria of 58 patients with endometriosis and in the endometria in 15 patients with hysteromyoma.Results The intensity of Fhit expression decreased in the order of normal endometrium,eutopic endometrium in endometriosis group,and ectopic endometrium.In patients with endometriosis,...